Which symptom is most indicative of Oral Cancer in its advanced stages?

In advanced stages of oral cancer, a persistent ulcer that does not heal serves as a significant indicator of the disease. This type of ulceration typically reflects the underlying pathology of cancer, where abnormal cell growth disrupts the normal healing processes. The presence of a non-healing ulcer suggests that the tissue is not regenerating properly due to malignant transformation and extensive local tissue involvement.

Persistent ulcers can result from the cancer invading surrounding tissues, and their chronicity is a hallmark sign that distinguishes oral cancer from other less serious conditions. While other symptoms like white patches, pain during meals, and bleeding gums may also occur in various oral health issues, they do not necessarily indicate advanced cancer. Specifically, white patches (leukoplakia) may represent precancerous lesions but are not definitive signs of invasive cancer. Pain during meals and bleeding gums can occur due to numerous oral health problems like infections or gum disease and are not specific to cancer.

Thus, a persistent, non-healing ulcer stands out as a clear and concerning symptom, warranting further evaluation for potential malignancy in the oral cavity.